If you are a “H63d carrier”  it means that you have inherited a single copy of the H63d variant from one of your parents. This is sometimes called a heterozygous carrier. Carriers are not usually at risk of iron loading. If you have normal iron levels and no symptoms, you will not require any further follow-up. If you have symptoms, you may need to be referred to the hospital for further investigations.

Implications for people with this genetic variant

  • There is no predictable risk of iron overload in people with one copy of the H63d gene alteration, and without the C282y gene alteration.
  • This genotype is very unlikely to cause a clinical presentation of genetic haemochromatosis or iron overload.
  • In the presence of significant raised ferritin and transferrin saturation levels, you will need to be referred to a gastroenterologist or haematologist to eliminate other causes of iron overload.

Family members